Pyoderma gangrenosum presents as a rapidly enlarging, very painful ulcer. It is one of a group of autoinflammatory disorders known as neutrophilic dermatoses. The name pyoderma gangrenosum is historical. The condition is not an infection (pyoderma), nor does it cause gangrene Pyoderma gangrenosum (PG) is a reactive non-infectious inflammatory dermatosis falling under the spectrum of the neutrophilic dermatoses. There are several subtypes, with 'classical PG' as the most common form in approximately 85% cases Pyoderma gangrenosum is a rare, inflammatory skin disease where painful pustules or nodules become ulcers that progressively grow. Pyoderma gangrenosum is not infectious. Treatments may include corticosteroids, ciclosporin, infliximab, or canakinumab. The disease was identified in 1930
What is pyoderma gangrenosum (PG)? Pyoderma gangrenosum (PG) is a chronic, recurrent skin disorder in which patients get small red bumps or blisters that can grow and join together to become large open sores, or ulcers. The number of ulcers that patients get can vary from a few in mild cases to many in more severe ones Pyoderma gangrenosum. Pyoderma gangrenosum (PG) is a reactive non-infectious inflammatory dermatosis falling under the spectrum of the neutrophilic dermatoses, which includes Sweet's syndrome and Behcet's syndrome. The incidence is thought to be approximately 0.63 per 100,000 with the median age at presentation of 59 years. 1 The sex incidence ranges from being equal, 2 to females being.
Treatment of pyoderma gangrenosum is aimed at reducing inflammation, controlling pain, promoting wound healing and controlling any underlying disease. Your treatment will depend on several factors, including your health and the number, size, depth and growth rate of your skin ulcers Pyoderma gangrenosum Pyoderma gangrenosum (dermatitis ulcerosa) is een vrij zeldzame (1:100.000) acuut optredende en progressieve ulceratie, die ernstige schade kan veroorzaken en soms moeiljk te behandelen is. Het kan elk deel v.d. huid aandoen, met een voorkeur voor onderbenen, abdomen, billen, en gezicht Pyoderma gangrenosum (PG) is a rare neutrophilic dermatosis that presents with rapidly developing, painful skin ulcers hallmarked by undermined borders and peripheral erythema. Epidemiological studies indicate that the average age of PG onset is in the mid-40s, with an incidence of a few cases per m Pyoderma Gangrenosum: Rare, affects those aged 40-60 usually. Painful nodule/pustule which rapidly progresses to become an enlarging ulcer usually on the legs/trunk. It usually starts quite suddenly, often at the site of a minor injury (pathergy) Pyoderma gangrenosum kan opstå overalt på huden, men ses først og fremmest på benene. Man kan være alment påvirket med feber, led- og muskelmerter. Sårene er som regel meget smertefulde. Tidlig diagnose og hurtig behandling mindsker risikoen for større udbredning af såret, og for dannelse af grimme ar, der kan blive resultatet, hvis.
Definition / general. Noninfectious neutrophilic dermatosis with painful nodules / pustules that progress to necrotic ulcers with a characteristic violaceous edge. Pyoderma gangrenosum is a diagnosis of exclusion based on clinical and histological findings Pyoderma gangrenosum (PG) is an inflammatory skin disorder that is characterized by small, red bumps or blisters (papules or nodules) that eventually erode to form swollen open sores (ulcerations). The size and depth of the ulcerations vary greatly, and they are often extremely painful Pyoderma gangrenosum er en sjelden, men alvorlig sårsykdom i huden. Sykdommen kan arte seg på ulike måter, noe som kan føre til feil og forsinket diagnose med betydelige arrskader i huden som resultat. I minst halvparten av tilfellene foreligger en underliggende systemisk sykdom - eksempelvis Crohns sykdom, ulcerøs kolitt, leddgikt, leukemi Pyoderma gangrenosum is a rare non-infectious dermatosis characterized by large, painful ulcerated purulent lesions most commonly over the pretibial region. It can be associated with a number of systemic diseases. Epidemiology It is most common..
Pyoderma gangrenosum of upper back. Initial lesion: bite-like, small, red papule or pustule (many patients attribute spider bite) Classic ulcerative form - usually on legs, deep ulceration, violaceous border along ulcer bed. Less common variants: 1) Peristomal pyoderma, 2) Genital pyoderma (must differentiate from STI), 3) Pyostomatitis. Pyoderma gangrenosum is an uncommon, ulcerative, cutaneous condition with distinctive clinical characteristics first described in 1930.1 In my referral practice, affiliated with a teaching hospital, we would expect to see between five and ten new patients per year. About half the patients are found to have an associated systemic disease. As with so many other skin diseases, this disorder is. Pyoderma gangrenosum may seem to be a serious condition but this rarely leads to death. There are generally two types of pyoderma gangrenosum. The first one is the typical which primarily develops on the legs. On the other hand, the atypical pyoderma gangrenosum appears on the hands as well as on other parts of the body.. Pyoderma gangrenosum (PG) is a rare ulcerating skin disease, difficult to recognize for both patients and doctors. When it's misdiagnosed and mistreated, it can be even more mentally and physically devastating. Ulcers form for a variety of reasons. They come from infections, diabetes, vasculitis, and many other triggers
Pyoderma gangrenosum is an uncommon, ulcerative cutaneous condition of uncertain etiology. It is associated with systemic diseases in at least 50% of patients who are affected. [ 1, 2] The diagnosis is made by excluding other causes of similar-appearing cutaneous ulcerations, including infection, malignancy, vasculitis, vasculopathy, venous. Pyoderma gangrenosum (PG) is an atypical ulceration of the skin with unknown aetiology, usually associated with autoimmune systemic illnesses and haematological malignancies. Diagnosis is based on clinical suspicion and exclusion of other conditions. Treatment options vary greatly, ranging from conservative local an Vegetative pyoderma gangrenosum It is a localized, non-aggressive form of pyoderma gangrenosum with verrucous and ulcerative lesions, which was termed superficial granulomatous pyoderma in 1988. 10 The condition originally described as malignant pyoderma and supposed to be a separate entity by Perry et al. 11 is now considered by most authors. Pyoderma gangrenosum or gangrenosum pyoderma refers to serious but rare disease of the skin in which painful pustule or nodule breaks down and then forms ulcer that enlarges progressively. The name, Pyoderma gangrenosum is related to that way in which the ulcers appear and look like Pyoderma gangrenosum (PG) is a prototypic autoinflammatory neutrophilic dermatosis characterized by a spectrum of clinical presentations with variable courses, and has an increased cytokine and chemokine expression in lesional skin [1, 2].PG is considered a 'diagnosis of exclusion' due to the lack of definitive laboratory or histopathological diagnostic criteria and is thus frequently.
A 40-year-old chef with severe ulcerative colitis and pyoderma gangrenosum of both lower legs was operated on because of his leg condition. An ileo-anal pouch promised the patient before operation could not be done because of his extreme obesity, and therefore total colectomy only was undertaken, leaving a short rectal segment behind in the. Pyoderma gangrenosum is a rare treatable cause of skin ulceration. Pyoderma gangrenosum belongs to a group of related conditions called neutrophilic dermatoses. Although it sounds similar to gangrene, it is not a type of gangrene. Pyoderma gangrenosum is not contagious and cannot be transferred from person to person. What causes pyoderma. Pyoderma gangrenosum is a serious condition that can progress quickly, so it's important to get it diagnosed and treated as soon as possible. Pyoderma gangrenosum belongs to a group of autoinflammatory skin diseases called neutrophilic dermatoses 5). Neutrophils are a type of white blood cell or leukocyte which form an early line of defense. Pyoderma gangrenosum is an inflammatory neutrophilic dermatosis characterized by the spontaneous appearance of large, painful, necrotic ulcers. Many systemic illnesses with an inflammatory component may be associated with onset of PG. Oropharyngeal and airway lesions have potentially serious anesthetic implications
Pyoderma gangrenosum (PG) is a rare, inflammatory, ulcerative disease. The clinical appearance of the ulceration is usually the first clue to this diagnosis. PG is a diagnosis of exclusion. The biopsy is not diagnostic and there are no biological markers of the disorder . Diagnosis of the condition is difficult due to a lack of biomarkers or other distinguishing features, and treatment can also be challenging Pyoderma gangrenosum is a rare but serious primary ulcerating condition of the skin that falls into the category of neutrophilic dermatoses. Currently, there is no definitive guideline or gold standard in management of pyoderma gangrenosum, as data from controlled clinical trials are scarce. This topic provides an evidence-based, always current review on management of pyoderma gangrenosum.
Pyoderma Gangrenosum is a rare but treatable cause of skin ulceration, autoinflammatory disorder causing neutrophils to infiltrate the skin; a biopsy at the ulcer edge would hopefully demonstrate this but can be absent in active treatment or where there has been a delay in diagnosis . Die Pyoderma gangraenosum ist eine nicht-infektiöse, ulzerierende Gangrän der Haut.. 2 Klinisches Bild. Am Beginn stehen multiple Papeln und Pusteln, die sich rasch vergrößern und konfluieren.Sie verfallen in der Folge und führen zur Ausbildung eines schmerzhaften Ulkus.Das Ulkus besitzt typischerweise eine zentrale Nekrosezone und zeigt im Randbereich am Übergang zur.
Pyoderma gangrenosum (PG) is a rare, neutrophilic dermatosis commonly associated with systemic disease. Although there are a number of PG variants, the classical presentation is that of a painful ulcer (or ulcers) that grows rapidly and develops an undermined purple edge. It is important to exclude other causes of ulcers including infection and factitious disease Pyoderma gangrenosum is a diagnosis of exclusion as no specific criteria have been determined to confirm the diagnosis. All other potential causes of similar lesions must be excluded prior to making the diagnosis Rationale: Pyoderma gangrenosum is a notoriously painful inflammatory wound. Manual debridement is contraindicated. SPMDs can help dramatically decrease pain and inflammation while gently continuously debriding wounds and promoting brisk wound healing. Bacteria are killed as they come in contact with silver PMDs
Pyoderma gangrenosum (nih.gov). Sign out A. Skin, Left Leg from Central Wound, Punch Biopsy: - Necrotic debris with underlying granulation tissue and benign connective tissue with superficial vasculitis, see comment. - NEGATIVE for skin surface. B Pyoderma gangrenosum is a rare skin disorder of unknown origin. Major symptoms include small pustules that develop into large ulcers at various sites on the body. It may or may not be associated with other illnesses. It often, but not invariably, reflects underlying systemic disease. (NORD/G. Eysenbach Pyoderma gangrenosum is a diagnosis of exclusion, and the misdiagnosis of pyoderma gangrenosum can result in substantial complications in patients who have other causes of severe cutaneous ulceration Pyoderma Gangrenosum is a rare but treatable cause of skin ulceration. It can happen anywhere on the body - it can start spontaneously or start following a surgical procedure. Pyoderma Gangrenosum lesions or wounds on the leg can be slow to heal because wounds on the legs heal more slowly that other parts of the body Pyoderma gangrenosum (PG) is an uncommon neutrophilic dermatosis that presents as an inflammatory and ulcerative disorder of the skin. In contrast to its name, PG is neither an infectious nor gangrenous condition. The most common presentation of PG is an inflammatory papule or pustule that progresses to a painful ulcer with a violaceous.
Pyoderma Gangrenosum Janet G, Hickman, M.D. From the Education and Research Foun- dation, Lynchburg, Virginia Pyoderma gangrenosum is a distinctive, cutaneous ulcation characterized by a raised, purple, tender, undermined border and an irregular, purulent base Pyoderma Gangrenosum Awareness. August 11, 2019 ·. Novartis that produces the IL-1 inhibitor Ilaris is now showing interest in Pyoderma Gangrenosum. Pyoderma gangrenosum (PG) is a rare, inflammatory, and necrotizing disease that belongs to the group of neutrophilic dermatosis.1, 2, 3 The pathogenesis of PG remains unknown Pyoderma gangrenosum can also develop at other sites, such as around a stoma in patients who have inflammatory bowel disease (peristomal pyoderma gangrenosum), on the genitals (genital pyoderma gangrenosum), or in sites other than the skin, such as the bones, cornea, central nervous system, heart, intestine, liver, lungs, or muscle. Pyoderma gangrenosum is a rare treatable cause of skin ulceration. Pyoderma gangrenosum belongs to a group of related conditions called neutrophilic dermatoses. Although it sounds similar to gangrene, it is not a type of gangrene. Pyoderma gangrenosum is not contagious and cannot be transferred from person to person Pyoderma gangrenosum (PG) is an inflammatory, noninfectious, ulcerative neutrophilic skin disease of uncertain etiology commonly misdiagnosed as an aggressive skin infection. Pustules form and give way to ulcers with a necrotic, undermined margin. PG can affect any age and take on a number of differing clinical presentations
Petty A, Whitley MJ, Balbaban A, et al. Pyoderma gangrenosum induced by secukinumab in a patient with psoriasis successfully treated with ustekinumab. J Am Acad Dermatol. 2020;6(8):731-733. 9: García Cámara P, Zubiri Ara ML, García López S. Ustekinumab in a patient with pyoderma gangrenosum and refractory Crohn's disease Ontology: Pyoderma Gangrenosum (C0085652) An idiopathic, rapidly evolving, and severely debilitating disease occurring most commonly in association with chronic ulcerative colitis. It is characterized by the presence of boggy, purplish ulcers with undermined borders, appearing mostly on the legs What is pyoderma gangrenosum? Pyoderma gangrenosum is a rare treatable cause of skin ulceration. Pyoderma gangrenosum belongs to a group of related conditions called neutrophilic dermatoses. Although it sounds similar to gangrene, it is not a type of gangrene. Pyoderma gangrenosum is not contagious and cannot be transferred from person to person
Pyoderma gangrenosum (aussi appelée pyodermite phagédénique ou phagédénisme géométrique) est une maladie qui provoque la nécrose des tissus, ce qui provoque des ulcères profonds, généralement sur les jambes.Quand les lésions surviennent, elles peuvent entraîner des plaies chroniques, très douloureuses, mais rarement mortelles Pyoderma gangraenosum auf dem Rücken eines Patienten. Das Pyoderma gangraenosum, auch Dermatitis ulcerosa genannt, ist eine schmerzhafte Erkrankung der Haut, bei der es großflächig, in der Regel an einer Stelle, zu einer Geschwürbildung ( Ulzeration oder Ulkus) und zu einem Absterben ( Gangrän) der Haut kommt Pyoderma Gangrenosum is a rare, non-contagious skin condition that results in the development of large, painful sores on your skin, typically on your legs. In the dermatology world, it is classified under the neutrophilic dermatoses umbrella of diseases, as are Sweet syndrome and Peristomal pyoderma Pyoderma gangrenosum support group. 499 likes. Hello everyone, I have made this page for my wife who has this desease. With the rarity of this painful desease it it hard to find new information about.. Pyoderma gangrenosum is a rare medical condition that causes the development of painful sores, which most often appear on the legs. Though the exact cause is unknown, the disorder seems to be linked to the immune system. Some underlying conditions can increase a person's risk of developing pyoderma gangrenosum
Pyoderma gangrenosum is a rare autoimmune condition that causes painful ulcers on the skin. About half of all patients also have other systemic conditions like inflammatory bowel disease (IBD) such as Crohn's disease and ulcerative colitis, blood diseases and blood cancers, rheumatoid arthritis, and ankylosing spondylitis Pyoderma gangrenosum. 2016 2017 2018 2019 2020 2021 Billable/Specific Code. L88 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for. pyoderma gangrenosum. ICD-10. L88. Piodermia zgorzelinowa. Piodermia zgorzelinowa, zgorzelinowe zapalenie skóry, PG (od łac. pyoderma gangrenosum) - rzadkie schorzenie skóry o niejasnej etiologii. Może być objawem innych chorób ogólnoustrojowych; niekiedy występuje jako zespół paranowotworowy
Pyoderma gangrenosum is a rare, severe skin disease in which progressive ulceration develops spontaneously or after skin trauma. Unrecognised pyoderma gangrenosum may result in the destruction of an entire leg or arm or large parts of the trunk, and the condition is potentially lethal Clinically, pyoderma gangrenosum (PG) is characterized by a rapidly progressive, painful cutaneous ulcer with an irregular, violaceous and undermined border. PG occurs most frequently on the lower extremities and the trunk of middle-aged individuals. The face is only very rarely affected Pyoderma Gangrenosum Photos . Click thumbnail to enlarge. Previous 1 2 3 Next. Pyoderma Gangrenosum. Atypical-Pyoderma-Gangrenosum-1.jpg. Pyoderma Gangrenosum. pyoderma-gangrenosum-1.jpg. Pyoderma Gangrenosum. pyoderma-gangrenosum-10.jpg. Pyoderma Gangrenosum. pyoderma-gangrenosum-11.jpg
Pyoderma gangrenosum is a medical problem which causes painful, large sores or ulcers to grow on the skin, often mostly on the legs. It is uncertain exactly what the cause of pyoderma gangrenosum is, but it can be shared with a medical disorder caused by the system of immunity Le pyoderma gangrenosum peut aussi se développer au niveau d'autres sites, tels qu'autour d'une stomie chez les patients qui ont une maladie inflammatoire de l'intestin (pyoderma gangrenosum péristomial), au niveau des organes génitaux (pyoderma gangrenosum génital), ou au niveau de sites autres que la peau, tels que les os, la cornée, le système nerveux central, le cœur, les intestins.
Pyoderma gangrenosum je poměrně vzácné dermatologické onemocnění, které postihuje především dospělé pacienty, a ojediněle se vyskytuje také u dětí starších 12 let. Onemocnění má chronický charakter, příčiny vzniku nejsou známy, obvykle je však jeho výskyt spojen s jinými systémovými onemocněními, například trávicíh Haavautuvassa ihotulehduksessa (pyoderma gangraenosum) ihoon syntyy laajoja huonosti paranevia haavaumia. Haavautuva ihotulehdus ohimossa. Haavautuva ihotulehdus (pyoderma gangrenosum) näkyy laajana ihopuutoksena, joka paljastaa ihon alla olevia kudoksia. Tämän haava kasvoi parissa viikossa Pyoderma gangrenosum (PG) is a rare inflammatory wound that is diagnosed once all other possibilities have been eliminated. It occurs mainly in middle-aged patients, 50% of whom have underlying autoimmune conditions. Treatment includes systemic corticosteroids, appropriate dressings, and adequate pain management Color Black White Red Green Blue Yellow Magenta Cyan Transparency Opaque Semi-Transparent Transparent. Window. Color Black White Red Green Blue Yellow Magenta Cyan Transparency Transparent Semi-Transparent Opaque. Font Size. 50% 75% 100% 125% 150% 175% 200% 300% 400%. Text Edge Style The use of high-potency topical corticosteroid therapy in patients with pyoderma gangrenosum (PG) is an effective first-line treatment that avoids the possible adverse effects associated with the use of systemic therapies, according to the results of a recent study. The large prospective cohort study included secondary care patients in the United Kingdom
Pyoderma gangrenosum is an ulcerative disorder that falls into the category of neutrophilic dermatoses. Pyoderma gangrenosum should not be confused with pyogenic granuloma, a completely separate entity but with an equally ill-fitting name. Despite its name, pyoderma gangrenosum is not caused by infection or gangrene pyoderma gangrenosum. A rare, ulcerating skin disease in which the skin is infiltrated by neutrophils. It is often found in people with other underlying illnesses, such as inflammatory bowel disease, rheumatoid arthritis, or some hematological malignancies. See: illustration Pyoderma gangrenosum is a disease that causes tissue to become necrotic, causing deep ulcers that usually occur on the legs. When they occur, they can lead to chronic wounds.Ulcers usually initially look like small bug bites or papules, and they progress to larger ulcers.Though the wounds rarely lead to death, they can cause pain and scarring.. The disease was identified in 1930
Pyoderma gangrenosum je onemocnění se zavádějícím názvem. Nejde o hnisavé onemocnění ani o gangrenózní proces, ale o chronické zánětlivé onemocnění kůže s tvorbou bolestivých ulcerací. Etiopatogeneze není zatím zcela objasněna, ale pravděpodobně se jedná o imunopatologii s dysfunkcí neutrofilů. Jde o vzácný stav. Pyoderma gangrenosum appears to be mediated by the immune system, but the exact cause is unknown. The lesion. Drugs used to treat Pyoderma Gangrenosum The following list of medications are in some way related to, or used in the treatment of this condition Overview of Pyoderma Gangrenosum. Pyoderma is a noninfectious, progressive necrotizing skin condition. The etiology of pyoderma is unclear. Half of patients have a systemic inflammatory condition such as ulcerative colitis, Crohn's disease, irritable- bowel syndrome, lupus, or rheumatoid arthritis Pyoderma gangrenosum (PG) is a skin disease which generally begins as a small bump that expands into an ulcer which progressively grows. The ulcers have well defined borders and are often painful. While the legs are often affected, lesions may form anywhere. It may begin in the area of a minor injury
Pyoderma Gangrenosum. Pyoderma gangrenosum is a chronic, neutrophilic, progressive skin necrosis of unknown etiology often associated with systemic illness and sometimes skin injury. Diagnosis is clinical. Treatment includes wound care and, based on severity, anti-inflammatory drugs or immunosuppressants Pyoderma gangrenosum is a rare condition where inflammation in your skin causes large leg ulcers (or sores). These ulcers can grow quickly, are very painful, and may get worse over time. At first, ulcers in the legs will look like tiny bug bites. Over time, they will get bigger and more swollen and may form an inflamed rash on your skin Pyoderma gangrenosum (PG) is a rare noninfectious neutrophilic dermatosis. Clinically it starts with sterile pustules that rapidly progress and turn into painful ulcers of variable depth and size. Ecthyma gangrenosum is a type of skin lesion characterized by vesicles or blisters which rapidly evolve into pustules and necrotic ulcers with undermined tender erythematous border. Ecthyma means a pus forming infection of the skin with an ulcer, gangrenosum refers to the accompanying gangrene or necrosis.It is classically associated with Pseudomonas aeruginosa bacteremia, but it is not.
Pioderma gangrenozum (Pyoderma gangrenosum) je bolest koja uzrokuje da tkivo postane nekrotično, što dovodi do dubokih ulceracija koje se obično javljaju na nogama. Kad do njih dođe, one mogu da prouzrokuju hronične rane.Čirevi obično u početku izgledaju kao mali ubodi buba, i oni se razvijaju u veće čireve Context Peristomal pyoderma gangrenosum (PPG), an unusual variant of pyoderma gangrenosum, has been reported almost exclusively in patients with inflammatory bowel disease (IBD) and is frequently misdiagnosed.. Objective To better characterize the clinical manifestations, diagnosis, and management of PPG.. Design, Setting, and Patients Retrospective analysis of 7 patients with PPG observed in. Pyoderma gangrenosum: An ulcerating condition of skin that results in heaped borders with a typical appearance. Pyoderma gangrenosum appears to be mediated by the immune system, but the exact cause is unknown. The lesion usually begins as a soft nodule on the skin that then ulcerates
This graph represents the publications / citations timeline. Citation data is based on known citations. Zoom-in: Drag the mouse while pressing the left mouse button Pyoderma gangrenosum. Pyoderma gangrenosum is associated with inflammatory bowel disease, rheumatoid arthritis and haematological malignancies but occasionally arises in otherwise healthy individuals.. Pyoderma gangrenosum results in acute and often severe ulceration characterised by an overhanging purple or black necrotic edge and severe pain. It most commonly arises on the lower legs but may. Pyoderma gangrenosum (PG) is a rare neutrophilic dermatosis characterized by formation of painful ulcers. This PrimeView describes the epidemiology, pathophysiology, diagnosis, management of PG. The main symptom of pyoderma gangrenosum is a painful skin sore. Sores may begin as small bumps from an injury. However, a sore can grow up to 7.9 in (inches) (20 cm [centimeters]). The sores often have purple edges that look worn Abstract. Parastomal pyoderma gangrenosum (PPG) is an unusual neutrophilic dermatosis characterized by painful, necrotic ulcerations occurring in the area surrounding an abdominal stoma. It typically affects young to middle-aged adults, with a slight female predominance. The underlying etiology for PPG remains enigmatic but aberrant immune response to injury may play a pivotal role
Pyoderma gangrenosum: a retrospective review of patient characteristics, comorbidities and therapy in 103 patients. Br J Dermatol. 2011 Dec. 165 (6):1244-50. . Media Gallery Classic, or typical. Pyoderma gangrenosum (PG) is a rare inflammatory cutaneous disease. Much of the underlying pathophysiology and etiology remain poorly understood, but PG is often associated with autoimmunity and chronic inflammatory and/or neoplastic diseases.1,2 The disease can be extremely variable in presentation with either single or multiple lesions presenting on various parts of the body A small randomized controlled trial examined the use of infliximab for the treatment of pyoderma gangrenosum. Thirty patients were randomized to infliximab (13) or placebo (17). At week 2, significantly more patients in the infliximab group had improved (46% vs. 6% placebo, respectively) Pyoderma gangrenosum après allogreffe de cellules souches hématopoïétiques. Le pyoderma gangrenosum (PG) est une dermatose neutrophilique rare qui peut compliquer l'évolution d'un certain nombre de maladies systémiques. Parmi ces dernières, les pathologies hématologiques représentent 3,5 % des cas Infliximab in treatment of idiopathic refractory childhood pyoderma gangrenosum (PG) We report a case of refractory idiopathic childhood pyoderma gangrenosum in a young boy who had suffered from this disease since 3 years of age. He had unfavorable responses and intermittent relapses under different combinations of cytotoxic and steroid therapies Pyoderma gangrenosum is a rare medical condition of the skin characterized by large and painful ulcers or sores on the skin, commonly on the legs. The exact cause of pyoderma gangrenosum is not known; however, according to experts, this occurs as a result of dysfunction of the immune system